Also in ancient times there was a tradition that the frogs of Serifos are speechless, which responds to several ancient writers. It seems there was the proverbial expression serifios frog or toad from Serifos for voiceless people.
Ancient coins from the 6th century onwards have found in Serifos, which depict Perseus, the head of Medusa or serifios frog, associated with the local worship of Perseus. In Roman times the island is a place of exile.
The history of Serifos in the Middle Ages is similar to that of the other Cyclades. When the Duchy of the Aegean was founded Serifos was reached the Italian noble family of the Gkizi brothers, who ruled as vassals of the Duke of the Aegean, while often it fell victim of pirates culminating the invasion of Hairedin Barbarossa in 1537. In 1566 the Cyclades islands came under the Ottoman Empire, where they remained until the Revolution of 1821.